The meaning of the Acronym BUFF is...

BUFF is

• Big Ugly Fat Fellow

More Meanings For BUFF:

• Big Ugly Friendly Fellow
• Big Ugly Fat Fellow
• Big Ugly Fat Flyer
• Buf Ugly Fat Fucker (B52 nickname)
• Big Ugly Fat Fellow
• Buffalo
• Buffalo (nickname for B-52 bomber)
• Buffer
• Basketball's Ultimate Fun Fellowship

BUFF is also in:

• Adults
• Funnies
• Military
• NASA
• Sports
• Veterinary